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Article

Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis.

Cell research - 1 Apr 2017

Chen Chider, Wang Dandan, Moshaverinia Alireza, Liu Dawei, Kou Xiaoxing, Yu Wenjing, Yang Ruili, Sun Lingyun, Shi Songtao

Abstract excerpt

Systemic sclerosis (SSc), an autoimmune disease, may cause significant osteopenia due to activation of the IL4Rα/mTOR pathway. Mesenchymal stem cell transplantation (MSCT) can ameliorate immune disorders in SSc via inducing immune tolerance. However, it is unknown whether MSCT rescues osteopenia phenotype in SSc. Here we show that MSCT can effectively ameliorate osteopenia in SSc mice by rescuing impaired lineage...

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Identifiers

PMID: 28106077
DOI: 10.1038/cr.2017.11
PMCID: PMC5385608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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