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Article

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

22 Dec 2014

Abstract excerpt

Fibrillin-1 (FBN1) deficiency-induced systemic sclerosis is attributed to elevation of interleukin-4 (IL4) and TGF-β, but the mechanism underlying FBN1 deficiency-associated osteopenia is not fully understood. We show that bone marrow mesenchymal stem cells (BMMSCs) from FBN1-deficient (Fbn1(+/-)) mice exhibit decreased osteogenic differentiation and increased adipogenic differentiation. Mechanistically, this...

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PMID: 25534817
DOI: 10.1084/jem.20140643

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