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Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective

18 Dec 2011

Abstract excerpt

The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging topic in aging research. Our comprehensive data mining revealed over 250 genes tightly associated with CS. Using systems biology tools, we found that CS is closely interconnected with aging, longevity and ARDs, either by sharing common genes and regulators or by protein-protein interactions and eventually by common signaling...

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PMID: 22184282
DOI: 10.18632/aging.100413

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