Article
The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2013
Zhou Ning, Singh Kamini, Mir Maria C, Parker Yvonne, Lindner Daniel, Dreicer Robert, Ecsedy Jeffrey A, Zhang Zhongfa, Teh Bin T, Almasan Alexandru, Hansel Donna E
Abstract excerpt
PURPOSE: Despite more than 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluated Aurora kinase A, identified as an upregulated candidate molecule in bladder cancer, as a potential th...
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