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Article

Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer

22 Jan 2015

Abstract excerpt

Aurora kinase A (AURKA) regulates the cell cycle checkpoint and maintains genomic integrity. AURKA is overexpressed in various malignant tumors and its upregulation induces chromosomal instability, which leads to aneuploidy and cell transformation. To investigate the role of AURKA in endometrial cancer, we evaluated the association of immunohistochemical expression of AURKA with clinicopathological factors....

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Identifiers

PMID: 25625960
DOI: 10.3892/ijo.2015.2842

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