IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis

Abstract excerpt

HIV-1 persistence in latent reservoirs during antiretroviral therapy (ART) is the main obstacle to virus eradication. To date, there is no marker that adequately identifies latently infected CD4 + T cells in vivo. Using a well-established ex vivo model, we generated latently infected CD4 + T cells and identified interferon-induced transmembrane protein 1 (IFITM1), a transmembrane antiviral factor, as being...