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Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

9 Apr 2021

Abstract excerpt

The major barrier to curing HIV-1 infection is a small pool of latently infected cells that harbor replication-competent viruses, which are widely considered the origin of viral rebound when antiretroviral therapy (ART) is interrupted. The difficulty in distinguishing latently infected cells from the vast majority of uninfected cells has represented a significant bottleneck precluding comprehensive understandings...

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PMID: 33835029
DOI: 10.7554/elife.63810

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