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Article

The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor.

The ISME journal - 1 May 2017

Westhoff Sanne, van Leeuwe Tim Marijn, Qachach Omar, Zhang Zheren, van Wezel Gilles Philippus, Rozen Daniel Eric

Abstract excerpt

At the high concentrations used in medicine, antibiotics exert strong selection on bacterial populations for the evolution of resistance. However, these lethal concentrations may not be representative of the concentrations bacteria face in soil, a recognition that has led to questions of the role of antibiotics in soil environments as well as the dynamics of resistance evolution during sublethal challenge. Here...

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Identifiers

PMID: 28094796
DOI: 10.1038/ismej.2016.194
PMCID: PMC5437928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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