Resistant traits in digital organisms do not revert preselection status despite extended deselection: implications to microbial antibiotics resistance.

Abstract excerpt

Antibiotics resistance is a serious biomedical issue as formally susceptible organisms gain resistance under its selective pressure. There have been contradictory results regarding the prevalence of resistance following withdrawal and disuse of the specific antibiotics. Here, we use experimental evolution in "digital organisms" to examine the rate of gain and loss of resistance under the assumption that there is...

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