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Article

Evolution of Resistance to Continuously Increasing Streptomycin Concentrations in Populations of Escherichia coli.

Antimicrobial agents and chemotherapy - 14 Dec 2015

Spagnolo Fabrizio, Rinaldi Conrad, Sajorda Dannah Rae, Dykhuizen Daniel E

Abstract excerpt

The evolution of antibiotic resistance in bacteria has become one of the defining problems in modern biology. Bacterial resistance to antimicrobial therapy threatens to eliminate one of the pillars of the practice of modern medicine. Yet, in spite of the importance of this problem, only recently have the dynamics of the shift from antibiotic sensitivity to resistance in a bacterial population been studied. In...

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Identifiers

PMID: 26666944
DOI: 10.1128/AAC.01359-15
PMCID: PMC4775953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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