Article
Evolution of high-level resistance during low-level antibiotic exposure.
Nature communications - 23 Apr 2018
Wistrand-Yuen Erik, Knopp Michael, Hjort Karin, Koskiniemi Sanna, Berg Otto G, Andersson Dan I
Abstract excerpt
It has become increasingly clear that low levels of antibiotics present in many environments can select for resistant bacteria, yet the evolutionary pathways for resistance development during exposure to low amounts of antibiotics remain poorly defined. Here we show that Salmonella enterica exposed to sub-MIC levels of streptomycin evolved high-level resistance via novel mechanisms that are different from those...
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