Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.

Alcoholism, clinical and experimental research - 1 Nov 2017

Yeung Ellen W, Craggs Jason G, Gizer Ian R

Abstract excerpt

Alcohol use disorder (AUD) is highly comorbid with chronic pain (CP). Evidence has suggested that neuroadaptive processes characterized by reward deficit and stress surfeit are involved in the development of AUD and pain chronification. Neurological data suggest that shared genetic architecture associated with the reward and stress systems may contribute to the comorbidity of AUD and CP. This monograph first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Brain
Share to Chronic Pain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comorbidity

Share to Genetic Predisposition to Disease

Share to Neural Pathways

Share to Reward

Share to Stress, Psychological

Source

Open in PubMed Open full text

Identifiers

PMID: 29048744
DOI: 10.1111/acer.13491
PMCID: PMC5679730

Genes

HTR7
TBX19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems.PMID 29048744Read ↗

Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.Semantic proximity Read ↗

Genetic overlap of chronic pain, musculoskeletal-specific pain, substance use disorders and substance use consumption: Common addiction and substance-specific effects.Semantic proximity Read ↗

Hypothesizing that brain reward circuitry genes are genetic antecedents of pain sensitivity and critical diagnostic and pharmacogenomic treatment targets for chronic pain conditionsSemantic proximity Read ↗

Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubricSemantic proximity Read ↗

Genetic and epigenetic epidemiology of chronic widespread painSemantic proximity Read ↗

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence.Semantic proximity Read ↗

High Genetic Addiction Risk Score (GARS) in Chronically Prescribed Severe Chronic Opioid Probands Attending Multi-pain Clinics: an Open Clinical Pilot Trial.Semantic proximity Read ↗

Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics.Semantic proximity Read ↗

Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analysesSemantic proximity Read ↗

Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y geneSemantic proximity Read ↗

Crosstalk between alcohol use disorder and obesity: two sides of the same coin?Semantic proximity Read ↗

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.