TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

doi:10.7554/eLife.21615

Article

TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.

eLife - 16 Jan 2017

Pal Debjani, Pertot Anja, Shirole Nitin H, Yao Zhan, Anaparthy Naishitha, Garvin Tyler, Cox Hilary, Chang Kenneth, Rollins Fred, Kendall Jude, Edwards Leyla, Singh Vijay A, Stone Gary C, Schatz Michael C, Hicks James, Hannon Gregory J, Sordella Raffaella

Abstract excerpt

Many lines of evidence have indicated that both genetic and non-genetic determinants can contribute to intra-tumor heterogeneity and influence cancer outcomes. Among the best described sub-population of cancer cells generated by non-genetic mechanisms are cells characterized by a CD44+/CD24- cell surface marker profile. Here, we report that human CD44+/CD24- cancer cells are genetically highly unstable because of...

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