Article
CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity.
Cancer research - 1 Jul 2016
Boyle Samantha E, Fedele Clare G, Corbin Vincent, Wybacz Elisha, Szeto Pacman, Lewin Jeremy, Young Richard J, Wong Annie, Fuller Robert, Spillane John, Speakman David, Donahoe Simon, Pohl Miklos, Gyorki David, Henderson Michael A, Johnstone Ricky W, Papenfuss Anthony T, Shackleton Mark
Abstract excerpt
The stability of markers that identify cancer cells that propagate disease is important to the outcomes of targeted therapy strategies. In human melanoma, conflicting data exist as to whether hierarchical expression of CD271/p75/NGFR (nerve growth factor receptor) marks cells with enriched tumorigenicity, which would compel their specific targeting in therapy. To test whether these discrepancies relate to...
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