Article
Circadian Forced Desynchrony of the Master Clock Leads to Phenotypic Manifestation of Depression in Rats.
eNeuro - 1 Jan 2000
Ben-Hamo Miriam, Larson Tracy A, Duge Leanne S, Sikkema Carl, Wilkinson Charles W, de la Iglesia Horacio O, González Mónica M C
Abstract excerpt
In mammals, a master circadian clock within the suprachiasmatic nucleus (SCN) of the hypothalamus maintains the phase coherence among a wide array of behavioral and physiological circadian rhythms. Affective disorders are typically associated with disruption of this fine-tuned "internal synchronization," but whether this internal misalignment is part of the physiopathology of mood disorders is not clear. To date,...
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