Article
Sex-specific diurnal immobility induced by forced swim test in wild type and clock gene deficient mice.
International journal of molecular sciences - 25 Mar 2015
Li Ningyue, Xu Yanhua, Chen Xiaojuan, Duan Qing, Zhao Mei
Abstract excerpt
OBJECTIVE: The link between alterations in circadian rhythms and depression are well established, but the underlying mechanisms are far less elucidated. We investigated the circadian characteristics of immobility behavior in wild type (WT) mice and mice with mutations in core Clock genes. METHODS: All mice were tested with forced swim test (FST) at 4 h intervals. RESULTS: These experiments revealed significant...
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