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Article

Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats.

Proceedings of the National Academy of Sciences of the United States of America - 25 Mar 2008

Gonzalez M M C, Aston-Jones G

Abstract excerpt

Light is an important environmental factor for regulation of mood. There is a high frequency of seasonal affective disorder in high latitudes where light exposure is limited, and bright light therapy is a successful antidepressant treatment. We recently showed that rats kept for 6 weeks in constant darkness (DD) have anatomical and behavioral features similar to depressed patients, including dysregulation of...

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PMID: 18347342
DOI: 10.1073/pnas.0703615105
PMCID: PMC2290795

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