Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

doi:10.1126/science.aan5061

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Article

Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

Science (New York, N.Y.) - 22 Sept 2017

Tarvin Rebecca D, Borghese Cecilia M, Sachs Wiebke, Santos Juan C, Lu Ying, O'Connell Lauren A, Cannatella David C, Harris R Adron, Zakon Harold H

Abstract excerpt

Animals that wield toxins face self-intoxication. Poison frogs have a diverse arsenal of defensive alkaloids that target the nervous system. Among them is epibatidine, a nicotinic acetylcholine receptor (nAChR) agonist that is lethal at microgram doses. Epibatidine shares a highly conserved binding site with acetylcholine, making it difficult to evolve resistance yet maintain nAChR function. Electrophysiological...

Topics

Acetylcholine
Adaptation, Biological
Amino Acid Substitution
Animals
Anura
Binding Sites
Bridged Bicyclo Compounds, Heterocyclic
Drug Resistance
Electrophysiological Phenomena
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Phylogeny

Protein Conformation, beta-Strand

Pyridines

Receptors, Nicotinic

Source

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Identifiers

PMID: 28935799
DOI: 10.1126/science.aan5061
PMCID: PMC5834227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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