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Article

Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples.

Psychiatry research - 1 Apr 2021

Terock Jan, Weihs Antoine, Teumer Alexander, Klinger-König Johanna, Janowitz Deborah, Grabe Hans J

Abstract excerpt

Previous studies suggested that childhood trauma and a disturbed serotonergic neurotransmission are involved in the pathogenesis of alexithymia. Specifically, genetic polymorphisms of the serotonin receptors 5-HT1A and 5-HT2A were found to be associated with alexithymia. However, it is unclear whether these factors show main or interaction effects with childhood trauma on alexithymia. Data from two independent...

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PMID: 33567384
DOI: 10.1016/j.psychres.2021.113783

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