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Article

T Cell Maturation Stage Prior to and During GMP Processing Informs on CAR T Cell Expansion in Patients

26 Dec 2016

Abstract excerpt

Autologous T cells were genetically modified to express a Chimeric Antigen Receptor (CAR) directed towards carboxy-anhydrase-IX (CAIX) and used to treat patients with CAIX-positive metastatic renal cell carcinoma. In the present study, we questioned whether the T cell maturation stage in the pre-infusion product affected CAIX CAR expression and function in vitro as well as in vivo CAR T cell numbers and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28082983
DOI: 10.3389/fimmu.2016.00648

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