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Culture expansion of CAR T cells results in aberrant DNA methylation that is associated with adverse clinical outcome

14 Jul 2023

Abstract excerpt

Chimeric antigen receptor (CAR) T cells provide new perspectives for treatment of hematological malignancies. Manufacturing of these cellular products includes culture expansion procedures, which may affect cellular integrity and therapeutic outcome. In this study, we investigated culture-associated epigenetic changes in CAR T cells and found continuous gain of DNAm, particularly within genes that are relevant...

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PMID: 37452103
DOI: 10.1038/s41375-023-01966-1

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