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Article

Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

2 Oct 2010

Abstract excerpt

Adoptive transfer of immune effector cells that are gene modified by retroviral transduction to express tumor-specific receptors constitutes an attractive approach to treat cancer. In patients with metastatic renal cell carcinoma, we performed a study with autologous T cells genetically retargeted with a chimeric antibody receptor (CAR) directed toward carbonic anhydrase IX (CAIX), an antigen highly expressed in...

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PMID: 20889925
DOI: 10.1182/blood-2010-07-294520

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