Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Schwab Robert D, Bedoya Darel Martínez, King Tiffany R, Levine Bruce L, Posey Avery D

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapies are ex vivo manufactured cellular products that have been useful in the treatment of blood cancers and solid tumors. The quality of the final cellular product is influenced by several amenable factors during the manufacturing process. This review discusses several of the influences on cell product phenotype, including the raw starting material, methods of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cell Culture Techniques
Share to Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy, Adoptive

Share to Lymphocyte Activation

Share to Receptors, Antigen, T-Cell

Share to Receptors, Chimeric Antigen

Share to T-Lymphocytes

Source

Identifiers

PMID: 31707678
DOI: 10.1007/978-1-0716-0146-4_15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Approaches of T Cell Activation and Differentiation for CAR-T Cell Therapies.PMID 31707678Read ↗

Advancing cell-based cancer immunotherapy through stem cell engineeringSemantic proximity Read ↗

T Cell Activators Exhibit Distinct Downstream Effects on Chimeric Antigen Receptor T Cell Phenotype and Function.Semantic proximity Read ↗

Revolutionizing CAR T Cell Therapies: Innovations in Genetic Engineering and Manufacturing to Enhance Efficacy and AccessibilitySemantic proximity Read ↗

Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumoursSemantic proximity Read ↗

CAR-T cell expansion platforms yield distinct T cell differentiation statesSemantic proximity Read ↗

Chimeric Antigen Receptor T-Cell Therapy: What We Expect SoonSemantic proximity Read ↗

CD8+ chimeric antigen receptor T cells manufactured in absence of CD4+ cells exhibit hypofunctional phenotype.Semantic proximity Read ↗

Beyond ex vivo and in vivo CAR T: antigen-driven CAR T (adCAR-T) expansion method enables rapid, physiological CAR T cells programmingSemantic proximity Read ↗

Chimeric antigen receptor transduced T cells: Tuning up for the next generationSemantic proximity Read ↗

Development of a 3-day manufacturing method to generate CD19-CD20-CD22 trispecific CAR T-cells from whole blood.Semantic proximity Read ↗

CAR NK Cells: The Future Is NowSemantic proximity Read ↗

High-dimensional temporal mapping of CAR T cells reveals phenotypic and functional remodeling during manufacturing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.