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Article

The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats.

International journal of cardiology - 1 Apr 2017

Feng Ying, Liu Jianfang, Wang Menglong, Liu Menglin, Shi Lei, Yuan Wenhui, Ye Jing, Hu Dan, Wan Jun

Abstract excerpt

BACKGROUND: The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium (KATP) channel has been implicated in cardiac remodeling. However, the effects of E23K variant on ventricular electrophysiology and arrhythmogenesis remain unclear. METHODS: Transgenic rats were generated to express human E23K-variant genomic DNA in the heart under the α-myosin heavy chain promoter. Electrophysiological parameters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Reperfusion Injury

Share to Potassium Channels, Inwardly Rectifying

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Source

Identifiers

PMID: 28082085
DOI: 10.1016/j.ijcard.2017.01.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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