Article
Study of Kir6.2/KCNJ11 gene in a sudden cardiac death pedigree.
Molecular biology reports - 1 Jun 2008
Wan Jun, Xiong Chenling, Zheng Fang, Zhou Xin, Huang Congxin, Jiang Hong
Abstract excerpt
In clinic, the patients with acute myocardial infarction (AMI) are at high risk to develop ischemia-induced ventricular arrhythmias leading to sudden cardiac death (SCD). Some studies suggest that individual susceptibility to ischemia-induced arrhythmia may be related to the genes encoding ion channels. One of them is the cardiac ATP-sensitive potassium channel (K(ATP)), which is an octamer composed of four...
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