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Article

Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes.

Journal of pharmacological sciences - 1 Sept 2017

Watanabe Yasuhiro, Matsumoto Akio, Miki Takashi, Seino Susumu, Anzai Naohiko, Nakaya Haruaki

Abstract excerpt

Genetic analysis of KCNJ8 has pointed a mutation (S422L) as a susceptible link to J wave syndrome (JWS). In vitro expression study indicated that the ATP-sensitive K+ (KATP) channel with the S422L mutation has the gain-of-function with reduced sensitivity to ATP. However, the electrophysiological impact of KCNJ8 has not been elucidated in vivo. Transgenic mouse strains overexpressing KCNJ8 S422L variant (TGmt) or...

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Source

Identifiers

PMID: 28928055
DOI: 10.1016/j.jphs.2017.08.009

Genes

KCNJ8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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