Article
The complex genetics of gait speed: genome-wide meta-analysis approach.
Aging - 10 Jan 2017
Ben-Avraham Dan, Karasik David, Verghese Joe, Lunetta Kathryn L, Smith Jennifer A, Eicher John D, Vered Rotem, Deelen Joris, Arnold Alice M, Buchman Aron S, Tanaka Toshiko, Faul Jessica D, Nethander Maria, Fornage Myriam, Adams Hieab H, Matteini Amy M, Callisaya Michele L, Smith Albert V, Yu Lei, De Jager Philip L, Evans Denis A, Gudnason Vilmundur, Hofman Albert, Pattie Alison, Corley Janie, Launer Lenore J, Knopman Davis S, Parimi Neeta, Turner Stephen T, Bandinelli Stefania, Beekman Marian, Gutman Danielle, Sharvit Lital, Mooijaart Simon P, Liewald David C, Houwing-Duistermaat Jeanine J, Ohlsson Claes, Moed Matthijs, Verlinden Vincent J, Mellström Dan, van der Geest Jos N, Karlsson Magnus, Hernandez Dena, McWhirter Rebekah, Liu Yongmei, Thomson Russell, Tranah Gregory J, Uitterlinden Andre G, Weir David R, Zhao Wei, Starr John M, Johnson Andrew D, Ikram M Arfan, Bennett David A, Cummings Steven R, Deary Ian J, Harris Tamara B, Kardia Sharon L R, Mosley Thomas H, Srikanth Velandai K, Windham Beverly G, Newman Ann B, Walston Jeremy D, Davies Gail, Evans Daniel S, Slagboom Eline P, Ferrucci Luigi, Kiel Douglas P, Murabito Joanne M, Atzmon Gil
Abstract excerpt
Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and...
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