Article
Genetics of physiological dysregulation: findings from the long life family study using joint models.
Aging - 1 Apr 2020
Arbeev Konstantin G, Bagley Olivia, Ukraintseva Svetlana V, Wu Deqing, Duan Hongzhe, Kulminski Alexander M, Stallard Eric, Christensen Kaare, Lee Joseph H, Thyagarajan Bharat, Zmuda Joseph M, Yashin Anatoliy I
Abstract excerpt
Recently, Mahalanobis distance (DM) was suggested as a statistical measure of physiological dysregulation in aging individuals. We constructed DM variants using sets of biomarkers collected at the two visits of the Long Life Family Study (LLFS) and performed joint analyses of longitudinal observations of DM and follow-up mortality in LLFS using joint models. We found that DM is significantly associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.