Article
GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.
Aging cell - 1 Oct 2016
Matteini Amy M, Tanaka Toshiko, Karasik David, Atzmon Gil, Chou Wen-Chi, Eicher John D, Johnson Andrew D, Arnold Alice M, Callisaya Michele L, Davies Gail, Evans Daniel S, Holtfreter Birte, Lohman Kurt, Lunetta Kathryn L, Mangino Massimo, Smith Albert V, Smith Jennifer A, Teumer Alexander, Yu Lei, Arking Dan E, Buchman Aron S, Chibinik Lori B, De Jager Philip L, Evans Denis A, Faul Jessica D, Garcia Melissa E, Gillham-Nasenya Irina, Gudnason Vilmundur, Hofman Albert, Hsu Yi-Hsiang, Ittermann Till, Lahousse Lies, Liewald David C, Liu Yongmei, Lopez Lorna, Rivadeneira Fernando, Rotter Jerome I, Siggeirsdottir Kristin, Starr John M, Thomson Russell, Tranah Gregory J, Uitterlinden André G, Völker Uwe, Völzke Henry, Weir David R, Yaffe Kristine, Zhao Wei, Zhuang Wei Vivian, Zmuda Joseph M, Bennett David A, Cummings Steven R, Deary Ian J, Ferrucci Luigi, Harris Tamara B, Kardia Sharon L R, Kocher Thomas, Kritchevsky Stephen B, Psaty Bruce M, Seshadri Sudha, Spector Timothy D, Srikanth Velandai K, Windham B Gwen, Zillikens M Carola, Newman Anne B, Walston Jeremy D, Kiel Douglas P, Murabito Joanne M
Abstract excerpt
Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta-analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27 581 individuals of...
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