BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

doi:10.1016/j.ccell.2016.11.001

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Article

BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.

Cancer cell - 9 Jan 2017

López-García Carlos, Sansregret Laurent, Domingo Enric, McGranahan Nicholas, Hobor Sebastijan, Birkbak Nicolai Juul, Horswell Stuart, Grönroos Eva, Favero Francesco, Rowan Andrew J, Matthews Nicholas, Begum Sharmin, Phillimore Benjamin, Burrell Rebecca, Oukrif Dahmane, Spencer-Dene Bradley, Kovac Michal, Stamp Gordon, Stewart Aengus, Danielsen Havard, Novelli Marco, Tomlinson Ian, Swanton Charles

Abstract excerpt

Chromosomal instability (CIN) contributes to cancer evolution, intratumor heterogeneity, and drug resistance. CIN is driven by chromosome segregation errors and a tolerance phenotype that permits the propagation of aneuploid genomes. Through genomic analysis of colorectal cancers and cell lines, we find frequent loss of heterozygosity and mutations in BCL9L in aneuploid tumors. BCL9L deficiency promoted tolerance...

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PMID: 28073006
DOI: 10.1016/j.ccell.2016.11.001
PMCID: PMC5225404

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MDM2

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