Article
BMP15 regulates the inhibin/activin system independently of ovulation rate control in sheep.
Reproduction (Cambridge, England) - 1 Apr 2017
Estienne Anthony, Lahoz Belén, Jarrier Peggy, Bodin Loys, Folch José, Alabart José-Luis, Fabre Stéphane, Monniaux Danielle
Abstract excerpt
Polymorphisms in the gene encoding bone morphogenetic protein 15 (BMP15) have been associated with multiple ovulations in sheep. As BMP15 regulates inhibin expression in rodents, we assumed that the ovarian inhibin/activin system could mediate part of the effect of BMP15 mutations in the regulation of ovulation rate in sheep. To answer this question, we have studied the effects of two natural loss-of-function...
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