A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed.

doi:10.1016/j.anireprosci.2008.01.005

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Article

A 17 bp deletion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed.

Animal reproduction science - 1 Jan 2009

Monteagudo Luis V, Ponz Ricardo, Tejedor M Teresa, Laviña Adolfo, Sierra Isidro

Abstract excerpt

Different mutations in the Bone Morphogenetic Protein 15 (BMP15) and the Growth Differentiation Factor 9 (GDF9) genes cause increased ovulation rate and infertility in a dosage-sensitive manner in sheep. They cause increased ovulation rate and twin and triplet births in heterozygotes, and complete primary ovarian failure in homozygotes resulting in total infertility. We are here presenting a novel mutation in the...

Topics

Animals
Animals, Newborn
Bone Morphogenetic Protein 15
DNA
Exons
Female
Fertility
Frameshift Mutation
Gene Deletion
Growth Differentiation Factor 9
Litter Size

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Pregnancy

Sequence Analysis, DNA

Sheep

Source

Open in PubMed

Identifiers

PMID: 18282670
DOI: 10.1016/j.anireprosci.2008.01.005

Genes

BMP15
GDF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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