Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.

Nature genetics - 1 Jul 2000

Galloway S M, McNatty K P, Cambridge L M, Laitinen M P, Juengel J L, Jokiranta T S, McLaren R J, Luiro K, Dodds K G, Montgomery G W, Beattie A E, Davis G H, Ritvos O

Abstract excerpt

Multiple ovulations are uncommon in humans, cattle and many breeds of sheep. Pituitary gonadotrophins and as yet unidentified ovarian factors precisely regulate follicular development so that, normally, only one follicle is selected to ovulate. The Inverdale (FecXI) sheep, however, carries a naturally occurring X-linked mutation that causes increased ovulation rate and twin and triplet births in heterozygotes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 15
Share to Bone Morphogenetic Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Growth Differentiation Factor 9

Share to Growth Substances

Share to Infertility, Female

Share to Intercellular Signaling Peptides and Proteins

Share to Oocytes

Share to Ovulation

Source

Identifiers

PMID: 10888873
DOI: 10.1038/77033

Genes

BMP15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.PMID 10888873Read ↗

Genetic mutations influencing ovulation rate in sheep.Semantic proximity Read ↗

Integral role of GDF-9 and BMP-15 in ovarian function.Semantic proximity Read ↗

Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).Semantic proximity Read ↗

Bmp15 mutations and ovarian function.Semantic proximity Read ↗

The oocyte and its role in regulating ovulation rate: a new paradigm in reproductive biology.Semantic proximity Read ↗

Major genes affecting ovulation rate in sheep.Semantic proximity Read ↗

Genome-wide identification of a regulatory mutation in <i>BMP15</i> controlling prolificacy in sheepSemantic proximity Read ↗

Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.Semantic proximity Read ↗

Patterns of expression of messenger RNAs encoding GDF9, BMP15, TGFBR1, BMPR1B, and BMPR2 during follicular development and characterization of ovarian follicular populations in ewes carrying the Woodlands FecX2W mutation.Semantic proximity Read ↗

The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disordersSemantic proximity Read ↗

Fecundity genes in sheep.Semantic proximity Read ↗

Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.