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Article

Portrait of DNA methylated genes predictive of poor prognosis in head and neck cancer and the implication for targeted therapy.

Scientific reports - 11 May 2021

Hier Jessica, Vachon Olivia, Bernstein Allison, Ibrahim Iman, Mlynarek Alex, Hier Michael, Alaoui-Jamali Moulay A, Maschietto Mariana, da Silva Sabrina Daniela

Abstract excerpt

In addition to chronic infection with human papilloma virus (HPV) and exposure to environmental carcinogens, genetic and epigenetic factors act as major risk factors for head and neck cancer (HNC) development and progression. Here, we conducted a systematic review in order to assess whether DNA hypermethylated genes are predictive of high risk of developing HNC and/or impact on survival and outcomes in...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33976322
DOI: 10.1038/s41598-021-89476-x
PMCID: PMC8113272

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