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Article

Association of integrin-β2 polymorphism and expression with the risk of rheumatoid arthritis and osteoarthritis in Egyptian patients.

BMC medical genomics - 29 Aug 2023

Selim Aliaa M, Elsabagh Yumn A, El-Sawalhi Maha M, Ismail Nabila A, Senousy Mahmoud A

Abstract excerpt

BACKGROUND: The genetic architecture of rheumatoid arthritis (RA) and osteoarthritis (OA) are still unclear. Although RA and OA have quite different causes, they share synovial inflammation, risk factors, and some disease-associated genes, including the integrin subunit β2 (ITGB2)/CD18 gene involved in extracellular matrix interactions and immune cell signaling. However, the functional role of ITGB2 genetic...

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PMID: 37644537
DOI: 10.1186/s12920-023-01635-3
PMCID: PMC10463674

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