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Article

Evaluation of receptor‐ligand mechanisms of dual‐targeted particles to an inflamed endothelium

1 Mar 2016

Abstract excerpt

Abstract Vascular‐targeted carriers (VTCs) are designed as leukocyte mimics, decorated with ligands that target leukocyte adhesion molecules (LAMs) and facilitate adhesion to diseased endothelium. VTCs require different design considerations than other targeted particle therapies; adhesion of VTCs in regions with dynamic blood flow requires multiple ligand‐receptor (LR) pairs that provide particle adhesion and...

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PMID: 28066821
DOI: 10.1002/btm2.10008

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