Article
Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm.
ACS nano - 27 May 2014
Howard Melissa, Zern Blaine J, Anselmo Aaron C, Shuvaev Vladimir V, Mitragotri Samir, Muzykantov Vladimir
Abstract excerpt
Targeted nanomedicine holds promise to find clinical use in many medical areas. Endothelial cells that line the luminal surface of blood vessels represent a key target for treatment of inflammation, ischemia, thrombosis, stroke, and other neurological, cardiovascular, pulmonary, and oncological conditions. In other cases, the endothelium is a barrier for tissue penetration or a victim of adverse effects. Several...
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