Article

Statistics to prioritize rare variants in family-based sequencing studies with disease subtypes

2023-09-30

Abstract excerpt

Family-based sequencing studies are increasingly used to find rare genetic variants of high risk for disease traits with familial clustering. In some studies, families with multiple disease subtypes are collected and the exomes of affected relatives are sequenced for shared rare variants. Since different families can harbor different causal variants and each family harbors many rare variants, tests to detect causa...

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Literature Corpus work: 516fc4ce-d1a5-574b-beda-d021d2b62f52
DOI: 10.1101/2023.09.28.560053

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