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Article

Weighted pedigree-based statistics for testing the association of rare variants.

BMC genomics - 24 Nov 2012

Shugart Yin Yao, Zhu Yun, Guo Wei, Xiong Momiao

Abstract excerpt

BACKGROUND: With the advent of next-generation sequencing (NGS) technologies, researchers are now generating a deluge of data on high dimensional genomic variations, whose analysis is likely to reveal rare variants involved in the complex etiology of disease. Standing in the way of such discoveries, however, is the fact that statistics for rare variants are currently designed for use with population-based data....

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Identifiers

PMID: 23176082
DOI: 10.1186/1471-2164-13-667
PMCID: PMC3827928

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