Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.

Antiviral research - 1 May 2017

Wang Yaxin, Cao Lin, Zhai Yangyang, Ma Jiaming, Nie Quandeng, Li Ting, Yin Zheng, Sun Yuna, Shang Luqing

Abstract excerpt

Enterovirus 71 (EV71) is one of the major etiological agents of human hand-foot-and-mouth disease (HFMD) worldwide. EV71 infection in young children and people with immunodeficiency causes severe symptoms with a high fatality rates. However, there is still no approved drugs to treat such infections. Based on our previous report of a peptide-aldehyde anti-EV71 protease, we present here a highly specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Discovery
Share to Enterovirus
Share to Enterovirus A, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hand, Foot and Mouth Disease

Share to Nitriles

Share to Phenylalanine

Share to Pyridones

Share to Vero Cells

Source

Identifiers

PMID: 28063993
DOI: 10.1016/j.antiviral.2017.01.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.PMID 28063993Read ↗

Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor.Semantic proximity Read ↗

Characterization of three small molecule inhibitors of enterovirus 71 identified from screening of a library of natural products.Semantic proximity Read ↗

Structure of human enterovirus 71 in complex with a capsid-binding inhibitorSemantic proximity Read ↗

Molecular docking study of various Enterovirus—A71 3C protease proteins and their potential inhibitorsSemantic proximity Read ↗

Leucoverdazyls as novel potent inhibitors of enterovirus replicationSemantic proximity Read ↗

Functional Insights into Silymarin as an Antiviral Agent against Enterovirus A71 (EV-A71).Semantic proximity Read ↗

Selective human enterovirus and rhinovirus inhibitors: An overview of capsid‐binding and protease‐inhibiting moleculesSemantic proximity Read ↗

Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry.Semantic proximity Read ↗

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo.Semantic proximity Read ↗

Inhibition of enterovirus 71 by adenosine analog NITD008.Semantic proximity Read ↗

A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus.Semantic proximity Read ↗

Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acidSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.