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Article

Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004

Lewinson Oded, Padan Etana, Bibi Eitan

Abstract excerpt

MdfA is an Escherichia coli multidrug-resistance transporter. Cells expressing MdfA from a multicopy plasmid exhibit multidrug resistance against a diverse group of toxic compounds. In this article, we show that, in addition to its role in multidrug resistance, MdfA confers extreme alkaline pH resistance and allows the growth of transformed cells under conditions that are close to those used normally by...

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Identifiers

PMID: 15371593
DOI: 10.1073/pnas.0405375101
PMCID: PMC521123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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