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Article

Mutational analysis of the Helicobacter pylori carbonic anhydrases.

FEMS immunology and medical microbiology - 1 May 2005

Stähler Frank Nils, Ganter Lynn, Lederer Kathrin, Kist Manfred, Bereswill Stefan

Abstract excerpt

In the gastric microenvironment, Helicobacter pylori is exposed to bicarbonate, urea and acid. Here it is demonstrated that both H. pylori carbonic anhydrases (CAs) are required for maintaining urease activity and therefore influence H. pylori urea resistance at neutral pH. Furthermore, the beta-CA is required for acid resistance as indicated by a growth defect of the corresponding mutant at low pH. The alpha-...

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Identifiers

PMID: 15866214
DOI: 10.1016/j.femsim.2004.10.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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