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Article

P2Y12 Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017

Niu Xuan, Pi Shu-Lan, Baral Suraj, Xia Yuan-Peng, He Quan-Wei, Li Ya-Nan, Jin Hui-Juan, Li Man, Wang Meng-Die, Mao Ling, Hu Bo

Abstract excerpt

OBJECTIVE: P2Y12 is a well-recognized receptor expressed on platelets and the target of thienopyridine-type antiplatelet drugs. However, recent evidence suggests that P2Y12 expressed in vessel wall plays a role in atherogenesis, but the mechanisms remain elusive. In this study, we examined the molecular mechanisms of how vessel wall P2Y12 mediates vascular smooth muscle cells (VSMCs) migration and promotes the...

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Identifiers

PMID: 28062501
DOI: 10.1161/ATVBAHA.116.308725

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