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Article

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.

Oncotarget - 31 Jan 2017

Lai Cheng-Wei, Chen Hsiao-Ling, Tu Min-Yu, Lin Wei-Yu, Röhrig Theresa, Yang Shang-Hsun, Lan Ying-Wei, Chong Kowit-Yu, Chen Chuan-Mu

Abstract excerpt

The AKR1A1 protein is a member of the aldo-keto reductase superfamily that is responsible for the conversion of D-glucuronate to L-gulonate in the ascorbic acid (vitamin C) synthesis pathway. In a pCAG-eGFP transgenic mouse line that was produced by pronuclear microinjection, the integration of the transgene resulted in a 30-kb genomic DNA deletion, including the Akr1A1 gene, and thus caused the knockout (KO) of...

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Identifiers

PMID: 28060768
DOI: 10.18632/oncotarget.14458
PMCID: PMC5352327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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