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Article

Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2003

Bonyadi Mortaza, Waldman Stephen D, Liu Danmei, Aubin Jane E, Grynpas Marc D, Stanford William L

Abstract excerpt

The cellular and molecular mechanisms that underlie age-dependent osteoporosis, the most common disease in the Western Hemisphere, are poorly understood in part due to the lack of appropriate animal models in which to study disease progression. Here, we present a model that shows many similarities to the human disease. Sca-1, well known for its expression on hematopoietic stem cells, is present on a subset of...

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Identifiers

PMID: 12732718
DOI: 10.1073/pnas.1036475100
PMCID: PMC156288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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