Article

CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength

2024-09-26

Abstract excerpt

<h4>ABSTRACT</h4> Autophagy is a recycling pathway in which damaged or dysfunctional proteins, protein aggregates, and organelles are delivered to lysosomes for degradation. Insufficiency of autophagy is thought to contribute to several age-related diseases including osteoporosis. Consistent with this, elimination of autophagy from the osteoblast lineage reduces bone formation and causes low bone mass. However, w...

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Literature Corpus work: f9bea3f7-8bc0-57be-a2be-a064ff335c82
DOI: 10.1101/2024.09.26.615175

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CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strengthDOI 10.1101/2024.09.26.615175Read

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