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Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC).

Vascular medicine (London, England) - 1 Jun 2024

Ferrante Elisa A, Cudrici Cornelia D, Rashidi Mahmood, Fu Yi-Ping, Huffstutler Rebecca, Carney Katherine, Chen Marcus Y, St Hilaire Cynthia, Smith Kevin, Bagheri Hadi, Katz James D, Ferreira Carlos R, Gahl William A, Boehm Manfred, Brofferio Alessandra

Abstract excerpt

BACKGROUND: Arterial calcification due to deficiency of CD73 (ACDC; OMIM 211800) is a rare genetic disease resulting in calcium deposits in arteries and small joints causing claudication, resting pain, severe joint pain, and deformities. Currently, there are no standard treatments for ACDC. Our previous work identified etidronate as a potential targeted ACDC treatment, using in vitro and in vivo disease models...

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Identifiers

PMID: 38568107
DOI: 10.1177/1358863X241235669
PMCID: PMC11608424

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