Article
Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models.
Scientific reports - 20 Jan 2017
Kurogi Syuji, Sekimoto Tomohisa, Funamoto Taro, Ota Tomomi, Nakamura Shihoko, Nagai Takuya, Nakahara Mai, Yoshinobu Kumiko, Araki Kimi, Araki Masatake, Chosa Etsuo
Abstract excerpt
Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database. From 1278 trap clones in the EGTC database, 52 candidate lines were selected in the first screening, determined based on...
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