Article
Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.
The Journal of biological chemistry - 24 Feb 2017
Xiao Xiangwei, Chen Congde, Guo Ping, Zhang Ting, Fischbach Shane, Fusco Joseph, Shiota Chiyo, Prasadan Krishna, Dong Henry, Gittes George K
Abstract excerpt
The mechanisms underlying the effects of exocrine dysfunction on the development of diabetes remain largely unknown. Here we show that pancreatic depletion of SMAD7 resulted in age-dependent increases in β cell dysfunction with accelerated glucose intolerance, followed by overt diabetes. The accelerated β cell dysfunction and loss of proliferation capacity, two features of β cell aging, appeared to be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.