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Article

IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts.

Haematologica - 1 Apr 2017

Bolzoni Marina, Ronchetti Domenica, Storti Paola, Donofrio Gaetano, Marchica Valentina, Costa Federica, Agnelli Luca, Toscani Denise, Vescovini Rosanna, Todoerti Katia, Bonomini Sabrina, Sammarelli Gabriella, Vecchi Andrea, Guasco Daniela, Accardi Fabrizio, Palma Benedetta Dalla, Gamberi Barbara, Ferrari Carlo, Neri Antonino, Aversa Franco, Giuliani Nicola

Abstract excerpt

Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary alterations are specifically present in bone marrow monocytes from patients with multiple myeloma, smoldering myeloma or monoclonal gammopathy of undetermined significance. We analyzed the immunophenotypic and transcriptional profiles of bone marrow CD14+ monocytes in a cohort of patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28057743
DOI: 10.3324/haematol.2016.153841
PMCID: PMC5395118

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